Dr. Edgar Zenteno Galindo

Isolation of immunophagocytosis inducing proteins

OBJECTIVES

• Study of the structure-function relationship between the saccharidic components of the macrophage membrane

SUMMARY

There are carbohydrates on the surface of all cells that participate as receptors of different factors including toxins, hormones, bacteria and viruses. The great structural diversity associated with carbohydrates allows us to suppose that they could participate in the same way in various cell communication processes. Specifically, the macrophage represents the first line of defense and, for this reason, we consider that one of the mechanisms regulating its activity is through the different processes in which its membrane components also participate. In order to evaluate our hypothesis, we have used different lectins whose specificity we have been able to identify and, in this way, we evaluated the effect these induce on immune response processes in in vivo and in vitro studies.

PARTICIPANTS

• Raúl Chávez S., M.Sc.
• Concepción Agundis M., M.Sc.
• Dr. Ricardo Lascurain L.
• Georgina Alvarez F., M.Sc.
• Lorena Vázquez N., M.Sc.
• Guadalupe Maldonado M., M.Sc.

BIBLIOGRAPHY

• 1. E Zenteno, L Vázquez, R Chávez, F Córdoba, J Wieruszeski. (1995) Specificity of the isolectins from the cactus plant. Machaerocereus eruca for oligosaccharides from Mucin. Glycoconj J. 12: 699-706.
• 2. L Vázquez, H Lanz, L Montańo and E Zenteno. (1994) Biological activity of the lectin from Macrobrachium resenbergii hemolymph. Lectins 10: 261-265.
• 3. R Lascurain, R Chávez, P Gorociaca, A Pérez, L Montańo and E Zenteno. (1994) Recognition of CD4+ mouse medullary thymocytes by Amaranthus leucocarpus lectin. Immunology 83 410-413.
• 4. G Maldonado, F Porras, L Vázquez and E Zenteno. (1994) Effect of lectins on the phagocytic activity Immunological Investigations 23: 429-436.
• 5. E Zenteno, M Ortega, J Montreuil and H. Debray. (1994) Fast purifications of Phaseolus vulgaris isolectins Preparative Biochemistry 24: 175-183.